INITIALLY PURPORTED HEPATOTOXICITY BY PELARGONIUM SIDOIDES: THE DILEMMA OF PHARMACOVIGILANCE AND PROPOSALS FOR IMPROVEMENT

Initially purported hepatotoxicity by Pelargonium sidoides: the dilemma of pharmacovigilance and proposals for improvement

Background.Spontaneous reports of herb induced liver injury (HILI) represent a major regulatory issue, and it is in the interest of pharmacovigilance to identify and quantify previously unrecognized adverse reactions and to confirm or refute false positive signals of safety concerns.In a total of 13 spontaneous cases, liver disease has initially be

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Dynamic Identification of the KUKA LBR iiwa Robot With Retrieval of Physical Parameters Using Global Optimization

This paper focuses on the problem of extracting the physical dynamic parameters which are fundamental for computing the positive-definite link mass matrix.To solve this problem, a minimal set of dynamic parameters were firstly identified by the standard least squares method.In order to simplify the vegas golden knights background dynamics model, a

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